In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate

Mohd Azam Khan Goriman Khan, and Che Nor Zarida C. S., and Fauziah O., (2011) In vitro elution and dissolution of tobramycin and gentamicin from calcium phosphate. [Indexed Article]

Official URL: http://www.academicjournals.org/ajpp/abstracts/abs...

Abstract

This study was conducted to investigate the in vitro drug release characteristics of tobramycin and gentamicin from calcium phosphate. Calcium phosphate beads were loaded with tobramycin and gentamicin separately to form 2 types of antibiotic beads to generate antibiotic drug delivery system for the treatment of osteomyelitis. Tobramycin and gentamicin concentrations were determined spectrophotometrically by measuring the absorbance at 400 nm. The standard graphs for tobramycin and gentamicin concentration versus absorbance reading were prepared as references to identify the concentration of the drugs release after incorporating calcium phosphate over 8 weeks. This study showed that incorporating tobramycin and gentamicin with calcium phosphate provided slow residual release of antibiotic from 30 min to 1344 h (8 weeks) and dissolution of calcium phosphate. In this respect, the drug delivery systems of tobramycin and gentamicin-incorporated calcium phosphate have potential of controlling drug release.

Item Type: Indexed Article
Keywords: Tobramycin - Gentamicin - Calcium phosphate- Drug delivery system - Osteomyelitis.
Faculty: Faculty of Veterinary Medicine
Deposited By: En. Pahmi Abdullah
Date Deposited: 27 Jun 2012 15:21
Last Modified: 07 Mar 2016 07:15
URI: http://umkeprints.umk.edu.my/id/eprint/564

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