Safety assessment of spray dried strobilanthes crispus aqueous extract on liver, kidney and biochemical profiles in sprague-dawley rats

Nurul Amira Buslima,, and Sabariah Mohd Noor,, and Fauziah Othman,, and Asmah Rahmat, (2015) Safety assessment of spray dried strobilanthes crispus aqueous extract on liver, kidney and biochemical profiles in sprague-dawley rats. Advances in Environmental Biology, 9 (19). pp. 146-153. ISSN 1998-1066

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Abstract

Nutraceutical products have been widely used nowadays to supplement for better health performance and scientific evidence on the safety level is important for consumption. Objective: Aim of this study was to evaluate the acute 14-days dose response toxicity of spray-dried Strobilanthes crispus aqueous extract supplementation on vital organs and important biochemical profiles. Materials and methods: Four different doses of spray-dried S. crispus (700, 2100, 3500 and 4900 mg /kg of body weight) were administered to 5 normal Sprague-Dawley rats to review and compare any possible changes in physical behaviour, biochemical parameters and organs morphology. Biochemical parameters tested include haematology, liver and kidney function tests. Result: Overall, there was no death and no significant toxicity was observed with respect to biochemical parameters and organ morphology compared to normal control group. However, dosage group of 2100 - 4900 mg/kg of body weight showed significant differences in sodium and chloride level as compared to control group. Abnormal morphological characteristics was found in liver tissues where the sinusoidal widening was found in dosage group of 3500 and 4900 mg/kg of body weight. Conclusion: In brief, findings on biochemical profile of spray-dried S. crispus aqueous extract verified that it is safe to be consumed at the highest dose tested in this study (4900 mg/kg of body weight) and histological observations provide support to less or negligible destructive nature on liver and kidney tissues.

Item Type: Non-Indexed Article
Uncontrolled Keywords: Acute toxicity, spray dried Strobilanthes crispus, liver function tets, kidney function test, biochemical test.
Faculty: Faculty of Agro - Based Industry
Depositing User: En. Pahmi Abdullah
Date Deposited: 21 May 2017 06:59
Last Modified: 21 May 2017 06:59
URI: http://umkeprints.umk.edu.my/id/eprint/5267
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